Following the most natural choice, Thutmose I married his only surviving son Thutmose II
to his only surviving daughter Hatshepsut; with respective
mothers Mutnofret and Ahmose, the two were half-brother and half-sister.

Thutmose II is remembered for being very young and very frail; he was probably
just a teenager when he married Hatshepsut, who may have been as young as twelve.
Thutmose I had engaged the country in all number of conquests, and it may be that Thutmose II
believed that the country was safe enough, or that he was too young to go to battle, but his
military exploits were few in number, and he did not personally participate even in those.

As Queen Consort, Hatshepsut bore the usual titles of King's Daughter, King's Sister, King's Great Wife
and her preferred title, God's Wife of Amon.

As he and Hatshepsut had no sons, Thutmose II's heir apparent at his death was his son Thutmose
from a lesser and quite unknown wife called Isis; a child probably younger than Neferure.
When Thutmose II died, Hatshepsut became regent for the little boy Thutmose III, probably planning
to marry him to her much-beloved daughter Neferure.